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Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis Syndrome

PFAPA is an auto-inflammatory disease; the fever episodes usually manifest themselves before the child is five years old. They begin at regular intervals, every 3-8 weeks with abruptly rising fever >39°C which spontaneously goes down after 3-6 days. These fever episodes are accompanied by the complex of symptoms after which the disease is named but also by headaches, nausea, vomiting and abdominal pain are typical features.

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